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It is thought that portal hypertension (high blood pressure in the livers venous system) due to NAFLD may impair the kidneys ability to regulate sodium levels and blood pressure, triggering dysfunctional compensatory mechanisms and setting the stage for CKD

ACE inhibitors (ACEIs) (e.g., first-line antihypertensive drugs, such as lisinopril, enalapril, captopril) are among the most commonly prescribed antihypertensive drugs and are widely used in the treatment of cardiovascular disorders [66]

In doing so, it addresses several of the abnormal and disease-causing factors associated with obesity

Martin-Loeches, C

How Supply and Demand for Weight Loss Drugs is Playing Out in 2026

doi:10.1007/s00394-023-03241-6