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For example, lung cancer cell-lines show different sensitivities to doxorubicin in the form of GSH depletion, with A549 and GLC 4 210(S) cells experiencing approximately 50% and 64% GSH depletion after a 12 hour exposure to 70 nM and 5 nM (per million cells) respectively 37
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All animal experiments were performed following approval by the Kermanshah University of Medical Sciences Institutional Animal Care and Use Committee (IACUC), and all methods were conducted under the relevant guidelines and regulations
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