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Primarily, early BT non-responders treated with phentermine achieved 5.9% weight loss from randomization to week 24, surpassing the 2.8% loss observed with placebo
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Twice-daily dosing is used in some early-phase research protocols to maintain more consistent receptor activation during the initial neuroplasticity induction period, but this approach increases total daily exposure and may elevate the risk of off-target effects
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