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In our recent studies, we identified which tests for muscle strength and physical function are most reproducible and sensitive in people with obesity

The clinical evidence favors a steady, moderate dose over intermittent higher doses

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The landmark FLOW trial , published in the New England Journal of Medicine in 2024, demonstrated that semaglutide reduced the risk of major kidney disease events by 24% in patients with type 2 diabetes and chronic kidney disease (hazard ratio 0.76

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It is produced by the kidneys, liver, and pancreas and can also be found in low quantities in red meat and fish (OPSS, 2025)