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The mean estimated ALSFRS-R total score was 42.8 at baseline, 30.6 at month 12 and 18.4 at month 24 in treated subjects, with a mean slope of 1.0, as compared to 41.9, 25.4 and 8.8 in not treated subjects, with a mean slope of 1.4 (slope difference: 0.4
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Moreover, it downregulates the protein levels of cell proliferation marker PCNA, decreases cell viability and number, and upregulates the protein levels of pro-apoptotic markers [91]
These strong clinical results have built trust among healthcare providers, leading to earlier and more frequent prescriptions of GLP-1 drugs
