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Due to its potent effects on glucose homeostasis and appetite regulation, GLP-1R agonists are treatments for type 2 diabetes and obesity [2, 3]
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Compared to endogenous receptor ligands, retatrutide exhibits a stronger affinity for the GIP receptor than for the glucagon and GLP-1 receptors [112]
The rate is highest during the first 16 weeks (the period of most rapid weight loss) and drops significantly after week 24
The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets
Post-marketing surveillance and clinical case series provide better signal
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