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The dual GLP-1/GIP receptor agonism mechanism addresses multiple hunger and metabolic pathways, explaining why tirzepatide often succeeds where single-pathway medications or diet-only approaches fail

Studies with complete reporting and rigorous design were rated as "High," while others with some limitations or missing methodological details were rated as "Medium" or "Low." To evaluate the reliability and scientific rigor of the evidence presented in this review, we conducted a methodological quality assessment of the primary clinical trials included

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Int.J Cardiol