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this ligand is then converted to the Y2-R agonist PYY 3-36 via enzymatic cleavage by DPPIV 69,70
Test subjects were randomly assigned to one of nine experimental treatments including once-weekly semaglutide in doses of 0.1, 0.2, 0.4, or 0.8 mg, once-weekly semaglutide with dose escalation (E) (0.8 or 1.6 mg E), once-daily active control (1.2 or 1.8 mg), or once-weekly placebo
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In a study in subjects with different degrees of hepatic impairment, no clinically relevant change in semaglutide pharmacokinetics was observed [see Clinical Pharmacology (12.3)]
121(43):e2412872121 Consequences of Obesity
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