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The toxicity can be explained by the tendency of these molecules to bind or destroy important biomolecules

However, several factors can compromise carnitine status: caloric restriction (which reduces dietary intake), certain medications, chronic kidney disease, and strict vegetarian or vegan diets

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Schad ML, McMillan GP, Thielman EJ, Groon K, Morse-Fortier C, Martin JL, Henry JA

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Chemotherapy-induced neurotoxicity: the value of neuroprotective strategies