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The majority of reported events occurred in patients who experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea
CSD is associated with significant cerebral vasoconstriction (13), which triggers neuronal swelling and activation of meningeal trigeminal nerve endings and the trigeminal vascular system, ultimately contributing to migraine development (1416)
This strategy has been applied to dulaglutide, where two GLP-1 molecules are fused to the Fc fragment of IgG4, increasing the half-life while reducing the renal elimination due to the increased molecular weight
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Current clinical studies on DOR primarily focus on genome sequencing and mutation identification, while the underlying disease mechanisms and signaling pathways remain underexplored
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