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Peripherally administered GLP-1R and GIPR agonists have also been shown to localize in CVOs, with limited labelling in brain regions shielded by the bloodbrain barrier 13,54,55
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The receptor system is complex, IR and IGF-1R genes can form several types of hybrid receptors such IGF-1R/IR-A, IGF-1R/IR-B, IR-A/IR-B, and others
Rodriguez MA, Montano JD, Williams RC
Los agonistas orales no peptdicos muestran un agonismo sesgado, favoreciendo las vas responsables de la secrecin de insulina y la activacin gnica, con una sealizacin ms selectiva
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