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Peptides can induce hormonal imbalances, potentially causing side effects such as mood fluctuations and decreased sexual performance

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Despite being identified as a promising candidate in 1998, ipamorelin never advanced through full clinical development

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Atherosclerosis 236 , 717 (2014)

This review synthesizes the mechanistic foundations of hypoxia-induced metabolic reprogramming, its role in tumor progression and therapeutic resistance, and discusses innovative strategies aimed at exploiting hypoxia-associated metabolic dependencies to advance precision oncology