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Chen X, Zaro JL, Shen WC (2013) Fusion protein linkers: property, design and functionality

The practical consequence: the conventional side-effects framework used for trial-backed peptides incidence percentages, discontinuation rates, dose-response curves from clinical data does not exist for Dihexa

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Re-testing every 3-6 months during ongoing therapy confirms sustained response and detects changes requiring protocol adjustment

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