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A third pathway involving cleavage of APP by - and -secretase independently of -secretase is also non-amyloidogenic and results in the secretion of 14-16 amino acid-long A [51]

Notably, among the principal components evaluated for the histology score, H4R / mice had significantly lower cellular infiltration and decreased overall mucosal damage in both Ox- and DSS-induced colitis (Figure 2d, hj)

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