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Blocking MR receptors and interfering with glucocorticoids stimulation of glutamate activity counteracted stress-induced suppression of the histone acetyltransferase p300 mRNA levels in the hippocampus, showing a link between glucocorticoids and epigenetic programming of the glutamatergic system [20]

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This finding raises the possibility that reduced statistical power due to a smaller sample size or differing pharmacologic actions between GLP1RAs and tirzepatide may have influenced the results

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