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The coupling of A-GSH targeting ligands resulted in significantly higher BBB penetrations for the 3-PLG-dopa-A-GSH nanocarriers both in the presence of organoids from healthy (3-PLG-dopa-A-GSH P app : 6.52 10 6 cm/s) and PD cells (3-PLG-dopa-A-GSH P app : 6.80 10 6 cm/s) compared to the permeability values of non-targeted formulations
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Because cancer cells do not take up aspartate very well, GOT fuels tumorigenesis by providing cytosolic aspartate, which is used as a precursor for protein and nucleotide synthesis and for redox homeostasis 32
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You may now have picked up some clues as to glutathiones benefits, but this compound really fulfillls many roles in the body
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