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One strategy to ameliorate this involves introducing a high-calorie diet, which was shown to extend survival in ALS mouse models and patients with fast-progressing ALS [302]

This genetic context may help provide insight into treatment response variability and support more informed medication selectionwhether compounded semaglutide, tirzepatide, or combination formulations

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(2025) reported that microglia exhibit region-specific increases and morphological alterations in response to combined MIA and repeated SDS stress (a two-hit mouse model, 2HIT)

Cell 135 , 907918 (2008)

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