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Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPAR pathway

By inhibiting lipid ROS generation and the hyperpolarization of mitochondrial membrane potential, mitoglitazone could restore mitochondrial DNA copy number, the generation of ATP, and mitochondrial morphology in kidney tissue, inhibiting mitochondrial dysfunction and ferroptosis induced by I/R

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JL and DF designed and revised the original manuscript

Heatmap results revealed decreasing immune cell enrichment in GLP-1R-high samples when compared to GLP-1R-low samples across these methods for a selection of key immune cells, further validating the phenomenon of GLP-1R-high samples having immune-cold tumor microenvironments

The duration of the result is also influenced by lifestyle and sun exposure habits