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Despite broad preclinical support, human data are extremely limited
Arancibia-Avila, P
The strongest evidence for heart protection currently comes from: Semaglutide (Ozempic, Wegovy) Dulaglutide (Trulicity) Liraglutide (Victoza) In fact, the FDA has specifically approved Dulaglutide and Semaglutide to reduce the risk of major cardiovascular events in certain high-risk adults
More importantly for arthritis, their knee pain dropped 41.7 points on the WOMAC scale versus 27.5 on placebo, with significantly better physical function a pain reduction larger than weight loss alone would explain
This weeks FDA approval of the first oral GLP-1 for weight loss by Novo Nordisk, cleared by the FDA, is a major milestone
Peptides can potentially improve symptoms, strengthen the skin barrier, and reduce inflammation, but they do not alter the underlying genetic predisposition
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