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Additionally, to simulate sepsis caused by polymicrobial infection and assess the impact of GLP-1RAs, the study utilized a cecal content injection method

Injectable glutathione is generally not recommended during pregnancy or lactation due to insufficient safety data in these populations

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Similarly, macrophage polarization exemplifies regulated immunometabolism: pro-inflammatory M1 macrophages exhibit high glycolytic activity to support iNOS-mediated NO production, whereas anti-inflammatory M2 macrophages depend on oxidative phosphorylation for tissue repair functions (58, 59)