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Each component is not FDA-approved and was removed from 503B bulk-compounding eligibility in 2024

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Topical preparations may use higher dilutions since they don't require injection-compatible volumes

Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig

Soluble dipeptidyl peptidase-4 induces fibroblast activation through proteinase-activated receptor-2

The funding source had no role in the design and conduct of the study