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Johns Hill Page 210 and 211: SUMMARY JENNIFER L

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This copper-binding tripeptide activates TGF-beta/SMAD pathway signaling, stimulates collagen I and III synthesis, upregulates TIMP-1 and TIMP-2 to protect collagen from degradation, and modulates gene expression across approximately 4,000 human genes

Dermal fibroblast isolation All animals were anaesthetized with ketamine (75 mgkg 1 ) and xylazine (10 mgkg 1 ), and their dorsal hair was carefully removed

There is also no consensus on biofeedbacks importance: some sources suggest it to be a last resort after other treatments have failed, while some researchers recommend it as first-line treatment (Basilisco 2013

Patient satisfaction was moderate