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Bottom line: The sulfur-rich cysteine in glutathione is what gives the molecule its "sticky" detoxifying power
M., Starfield, B., Sibbald, B., Salisbury, C
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The key mechanistic concept derived from these mouse studies was that the cellular toxicity was caused by a cytochrome P450-derived reactive metabolite, which was typically detoxified by GSH, but after the depletion of cellular GSH levels during an overdose, the reactive metabolite binds to cellular proteins thereby causing cell death [79]
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Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase
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