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SURMOUNT-1 (N=2,539) demonstrated 20.9% mean body weight reduction at 72 weeks with tirzepatide 15 mg versus 3.1% with placebo

Soon after, a similar inverse association has been found between NRF2 and miR-28 in human MCF7 breast cancer cells, where ectopic expression of miR-28 alone was able to reduce NFE2L2 mRNA and protein levels, and, as an abnormal miR-28 expression has been seen in a variety of cancers, a role in this regard has been hypothesized [222]

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