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These GLP-1 analogs affect glucose-dependent insulinotropic polypeptide receptors and glucagon receptors, in addition to GLP-1R and are expected to exhibit stronger anti-obesity effects than that of semaglutide [21, 22]

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"Efficacy and safety of novel twincretin tirzepatide a dual GIP and GLP-1 receptor agonist in the management of type-2 diabetes: A Cochrane meta-analysis"