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Tirzepatide (Zepbound) has shown the highest average weight loss in trials, at up to 21%, compared to about 14 to 18% for semaglutide (depending on form and dose) and 11% for oral orforglipron
American Medical Association (AMA)
550,551 Sudomotor dysfunction Gustatory sweating, a form of sudomotor dysfunction, is characterized by excessive sweating of the face and neck during eating, especially in response to spicy or acidic foods
Tirzepatide is an excellent option for those who find it challenging to lose weight with diet and exercise alone
Women with polycystic ovary syndrome (PCOS) are particularly often affected
Most people notice reduced hunger within the first four to eight weeks, followed by steady, gradual loss rather than dramatic swings
