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The promise of breakthrough drugs such as liraglutide and semaglutide to help people lose weight has been the subject of extensive media coverage in recent months, with Wegovy the latest such jab to be approved for use on the NHS for certain groups of people with obesity although it has yet to become available
Combined activation of GLP-1, GIP, and GCG systems theoretically provides complementary mechanisms: GLP-1-mediated insulin sensitization and satiety promotion, GIP-mediated enhancement of insulin secretion and adipose lipid buffering, and glucagon-mediated direct hepatic lipid oxidation and energy expenditure augmentation
Wang T, Fu X, Chen Q, Patra JK, Wang D, Wang Z, et al