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Initially, shots might be given more frequently to establish adequate levels, but over time, maintenance doses can be spaced out to once every few months
Especially the B12 form of methylcobalamin has proven to be very effective in many studies
sustained growth-hormone-axis stimulation also carries a theoretical, class-wide concern for worsened insulin resistance, a recognized effect of excess growth hormone exposure generally Evidence snapshot: The strongest available evidence is a small 1997 randomized, placebo-controlled human trial (19 adults aged 55-71) testing a closely related GHRH(1-29) analog over 16 weeks, which found increased IGF-1 in both sexes, a significant lean-mass increase in men only, and increased skin thickness in both sexes
It also significantly reduced inflammatory markers TNF-alpha and destructive enzymes MMP-2/MMP-9
The dosing schedules below mirror the protocols used in published Phase 3 clinical trials and are reported here for educational research context only
10.1016/s0014-2999(99)00486-0 54 KachlikD.BacaV.StinglJ
