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For comparison of continuous variables in different time points, Friedman (comparison of three time points) and Wilcoxon signed-rank test for related samples with post hoc Bonferroni corrections for multiple comparisons (comparison of two time points) were used

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The Control formulation (i.e., HA-only) includes Sequence 1 (i.e., HA-first) during V1V3 and Sequence 2 (i.e., GSH-C4-first) during V4V6