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These include severe abdominal pain, persistent vomiting with inability to tolerate fluids, visual changes (especially for people with diabetes and existing retinopathy), signs of allergic reaction (rash, difficulty breathing, facial swelling), right upper quadrant pain with fever or jaundice (possible gallbladder disease), or symptoms of thyroid tumors (neck mass, hoarseness, difficulty swallowing)

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(1992) characterized the binding kinetics of Long R3 IGF-1, establishing its reduced IGFBP affinity profile