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Ghosha AP, AlMamuna A, Lodowski P, Jaworska M, Kozlowski PM
Special populations: Patients with renal insufficiency: Patients with severe renal impairment should not be treated with chronic oral administration of high doses of levocarnitine because it can induce an accumulation of the potentially toxic metabolites trimethylamine (TMA) and trimethylamine-N-oxide (TMAO)
They need drugs that work through different mechanisms for non-responders
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GSH is predominantly in its thiol-reduced form inside the cells, except in the lumen of the endoplasmic reticulum where it exists only in its GSSG form (Figures 2, 4)
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