The compound did not advance to Phase 3 because the efficacy was insufficient for drug approval
Participants with renal impairment were recruited before those with normal renal function to help ensure similarity across groups in age and body weight
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6a), with the L7/S1 IVD used as a sham control
That said, tolerability is broadly similar across the three compounds: gastrointestinal adverse events dominate, and slow titration is the universal strategy for managing them