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Let's dive into why GLP-1 medications are changing everything for women with PCOS, and why the way they're prescribed matters just as much as the medication itself
Patients with HNF1A-MODY and HNF4A-MODY are initially sensitive to SU treatment, but glucose-stimulated insulin secretion in response to SUs decreases over time (at a rate of 1%4% per year), and patients often become unresponsive to SU treatment after 325 years.8 ,9 Although some patients remain responsive to SUs for more than 30 years, insulin treatment is frequently used for patients who become unresponsive to SUs
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These challenges contribute to many patients stopping GLP-1 therapy
Patients receiving semaglutide 2.4 mg in this trial lost 9.9% of their body weight, compared with 0.4% in those receiving placebo [33]
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