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GLP-1 receptor agonists: weight loss as trigger, bioenergetics as outcome GLP-1 reduces appetite and weight, but the downstream cascade is bioenergetic, resulting in less ectopic fat (hepatic/visceral), reduced lipotoxicity, and relief of ER/mitochondrial stress across the liver, muscle, and heart

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Saxagliptin added to a submaximal dose of sulfonylurea improves glycemic control compared with uptitration of sulfonylurea in patients with type 2 diabetes

ER stress was also alleviated by impairing either TCA-dependent NADPH production or Glutathione Reductase

doi: 10.1016/j.brainres.2018.03.015 292 SugitaH.MiyajimaC.DeguchiY