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This activation: Promotes directed cell migration toward injury sites Enhances cellular outgrowth from damaged tissue edges Improves cell survival during the stressful healing process Facilitates proper tissue organization This mechanism is particularly relevant for tendon and ligament healing, where cellular organization and proper fiber alignment are critical for functional recovery

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It seems that early initiation of anti-TNF- along with methotrexate and tight disease control provides the greatest potential of treatment holiday [148]

Expert Rev Pharmacoecon Outcomes Res