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Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

It hydrolyses DNA, which forms dense entanglements with mucin glycoproteins, reducing mucosal viscoelasticity by up to 50% 196

51:19 (2024) Kobayashi J, Sasaki D, Hara KY, Hasunuma T, Kondo A

Conclusions Overall, our study supported that metformin attenuates IIR-induced intestinal ferroptosis through modulation of the gut microbiota