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1 2 Ann Intern Med

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In addition to melatonin-related mechanisms, there is growing interest in uncovering the role played by circadian clock genes (such as CLOCK, BMAL1, PER1/2/3, CRY1/2, and NPAS2), which not only govern circadian timing but also regulate processes central to tumorigenesis, including cell cycle control, DNA damage response, metabolism, and immune regulation 25

Some users have reported mild side effects like stomach discomfort and nausea

Changes in GH signaling can affect the hormonal landscape more broadly