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Lower fluid intake and higher fluid loss reduce urine volume, and urine volume is one of the main determinants of stone risk, Wood explained

Perkins, R

If you accept the dual evidence that GLP-1/GCGR adds 3-6 percentage points of weight loss on top of GLP-1 alone, and you accept the tirzepatide evidence that GLP-1/GIPR adds 6-8 percentage points on top of GLP-1 alone, the arithmetic of a tri-agonist that captures both effects is intuitively additive

These new agents will radically change our approach to the treatment of T2DM and obesity alike

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The starting dose should always be the smallest available and titration should occur at frequent intervals, guided by pain scores and side effects