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El efecto sobre el receptor de GLP-1 resulta sesgado debido a la estructura de TZP con menor reclutamiento de beta arrestina-142, contribuyendo a una mayor potencia del efecto biolgico

A PubMed literature search used keywords, such as amyotrophic lateral sclerosis or ALS, as well as combinations of words using the controlled vocabulary thesaurus feature, Medical Subject Headings (MeSH)

Given its pivotal physiological role, researchers have developed GLP-1 receptor agonists (GLP-1 RAs) through structural modifications

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Peer review Peer review information Nature Reviews Drug Discovery thanks Timo Mller and the other anonymous reviewer/s for their contribution to the peer review of this manuscript