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Schmidt AC, Leroux JC Drug discovery today 2020
GLP-1s help to reduce the impacts of chronic stress and help to alter food reward pathways in positive ways and may help reduce alcohol and other substance use disorders (Mozafarriun et al 2025)
This drop-off may be attributed to a subset of patientsoften impulse buyersseeking rapid weight loss rather than committing to long-term therapeutic regimens
Sigalos and Pastuszak 2018 identified decreased insulin sensitivity and elevated fasting glucose as a consistent adverse signal across the entire GH secretagogue class, GHRH analogs included, even though the mechanism (preserved pulsatility) is theoretically gentler than fixed-dose GH
