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Trial registry Clinicaltrials.gov, Identifying number: NCT01720446, Date of registration: October 29, 2012 Similar content being viewed by others Background Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in people with type 2 diabetes (T2D) [1, 2], and diabetes itself confers a substantial independent risk of coronary heart disease, stroke, and death from other vascular causes [3]