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Small, frequent meals may be better tolerated than large meals given the medication's effects on gastric emptying
The combination of strong GLP-1 appetite suppression with meaningful GIP-mediated metabolic improvement creates a synergistic effect that exceeds what either receptor could produce alone, a principle similar to why peptide stacking sometimes outperforms individual compounds
Alcohol: Alcohol adds empty calories, impairs judgment around food choices, and can increase GI side effects
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Gupta NA, Mells J, Dunham RM et al (2010) Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
1723-1734 [Wiley] 34
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