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Managing Excessive Platelet Counts TPO-RAs can sometimes cause too many platelets, or thrombocytosis

They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding approximately 300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects

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In contexts of vascular disease or global effects, injection may remain the preferred method [2, 20, 24, 25]