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Craven et al., 2022

S-adenosylhomocysteine (SAH) generated from SAM via the transmethylation reaction is then hydrolyzed to form homocysteine (Hcy) and remethylated back to methionine through betaine-homocysteine S-methyltransferase (BHMT)

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Autophagy The impairment of autophagy and the clearance of accumulated, unwanted proteins play crucial roles in the development of neurodegeneration

Specifically, it features an amino acid substitution at position 8 (alanine to alpha-aminobutyric acid) to resist enzymatic breakdown, and a C18 fatty diacid side chain attached via a hydrophilic spacer at position 26 to enhance albumin binding