10.1038/nature03434 310 Nakagawa T., Shimizu S., Watanabe T., Yamaguchi O., Otsu K., Yamagata H., Inohara H., Kubo T., Tsujimoto Y., Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
10.1073/pnas.0602046103 91 DengJ.WangP.ChenX.ChengH.LiuJ.FushimiK.et al
However, if you have extremely reactive or compromised skin, we recommend performing a patch test on a small area first or consulting a dermatologist before full application
The positive stories you hear are personal reports, not scientific proof
12-17 Additionally, research has found omega-3 intake significantly improves disease markers of rheumatoid arthritis and reduces inflammatory leukotriene B4, which left to its own devices, could ultimately destroy joints
An additional open question is whether propagating ferroptotic injury contains reversible intermediate states before reaching tissue-scale collapse or whether spread proceeds as a strictly irreversible process once initiated