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5A) will provide more evidence on each agent to inform clinical decisions where reducing CV, HF or renal risk is a consideration
Available online at: (Accessed January 25, 2025)
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When administered, it helps the body produce more of its natural hormone
The effect of GLP-1 depends on blood glucose levels since it can only potentiate glucose-stimulated insulin secretion from islet beta cells in the hyperglycemic state rather than in the normal blood glucose state (95, 96)
Because this was not a randomized trial, we cannot say hormone therapy caused additional weight loss," says Maria Daniela Hurtado Andrade, M.D., Ph.D., endocrinologist at Mayo Clinic and senior author of the study
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