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64 Imbalances of gut bacteria, or dysbiosis, might further contribute to weight gain, obesity, and other metabolic disorders by amplifying inflammatory immune activity, enhancing faulty adipose tissue expansion, and contributing to insulin resistance

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Tirzepatide's established adverse effect profile includes gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation) in a substantial proportion of users, particularly during dose escalation

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