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RNA sequencing of efferocytic BMDCs revealed the upregulation of the Slc7a11 gene, cystine/glutamate transporter, that regulates intracellular glutamate for extracellular cysteine exchange and is highly expressed in skin-resident DCs
3 With elucidation of its mechanism, incidence, and impact on resistance to chemotherapy, interventions to decrease target concentrations of GSH may become part of future oncologic therapeutic regimens
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