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The FDA-approved prescribing information for semaglutide products (Ozempic, Wegovy, and Rybelsus) does not list nephrolithiasis (kidney stones) as a recognized adverse effect, and large-scale randomized controlled trials, including the SUSTAIN and STEP trial programs, have not identified kidney stones as a significant safety signal associated with semaglutide therapy

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Moreover, inhibiting CalcR-expressing NTS neurons increases food intake and partially prevents the appetite-suppressing effects of exendin-4, while their silencing leads to weight gain on a high-fat diet [61, 63]

Months 12: Silence "Food Noise" quiets down