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(Bataller and Brenner) Over time, this process results in the replacement of healthy liver tissue with non-functioning scar tissue

This model relies on many complex interactions, including branched chain amino acid cycling, but Rothman et al

10.1126/science.1128294 Science 140 PapadopoulosV.MillerW

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28.3) 5 , 6 After 2 to 4 days of primaquine ingestion, all the signs, symptoms, and laboratory results characteristic of an acute hemolytic episode are observed